Katharina Unger
Supervisor(s): Univ.Ass. Dr.techn. Manuela Waldner, MSc
TU Wien
Abstract: The Kyoto Encyclopaedia of Genes and Genomes
(KEGG) resource is a combination of multiple databases,
containing information about biochemical compounds, reactions,
pathways, genes and much more. This database
is one of the main resources for bioinformaticians and biologists
to gain an understanding of molecular functionality
inside organisms. The Orthology (KO) database from
KEGG assigns pathways and genes with identical functionality
to the same ortholog groups (KO entries). Therefore
it is possible to map genes onto the pathway maps
and obtain organism-specific visualizations. KEGG offers
a web-based graph visualization to explore these pathways,
however, the interaction possibilities are restricted
and the rendering is inefficient. It is possible to visualize
organism-specific pathways but a visual analysis tool to
compare ortholog groups of multiple organisms is missing.
In this work, we present an efficient interactive web application
to compare ortholog groups of multiple organisms
in the metabolic reference pathway. We introduce a graph
overlay technique to mark the differences and similarities
between multiple organisms and demonstrate it with two
use cases. Additionally, we compare it against an existing
point set membership visualization.
Keywords: Scientific Visualization
Full text: Year: 2019
